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WASHINGTON,
D.C., MAR 31,2000 (ZENIT.org).- The Human Genome Project
announced
Friday that 2/3 of the base pairs of the human DNA script have
already
been mapped. They further predict that by June, a working draft
of
90% of the genome (with 99.9% accuracy) will be completed.
Researchers
from around the world, mostly working for publicly funded
projects
in the U.S. and Great Britain, are inputing their results into
an
Internet database, making them available free of charge to all
scientists.
This
announcement is an attempt to beat private commercial enterprises,
which
are working on this same objective, but want to patent the
information.
The U.S. government's GenBank site, containing the known
part
of the genome, can be consulted freely at
http://www.ncbi.nlm.nih.gov/
, while the Human Genome Project homepage
is
located at http://www.nhgri.nih.gov/ .
The
genome is the set of genetic material characteristic of our species,
located
in the interior of cells. Its de-codification will fill in
important
holes in the development of therapies for the principal
illness
that affect us.
Herein,
precisely, is the great economic interest of private
researchers.
These companies hope to patent genetic data of therapeutic
potential,
so that scientists and laboratories wishing to study them
will
have to pay for the service.
In
all, there are some three billion "letters" constituting
the genetic
instruction
book of humans, each letter representing a base pair in a
DNA
chain. The two millionth base pair was input into the system by the
Wellcome
Trust's Sanger Centre in Great Britain. The "letter" was a
"T,"
the
abbreviation for thymine, one of the four chemicals or bases that
make
up DNA. The 2,178,076,000 unique base pairs now in GenBank have
also
been mapped to their locations on the 24 pairs of human
chromosomes.
Private
Competition
The
genome race is led by Celera Genomics. Its president, U.S.
geneticist
Craig Venter, announced that his version of the data will be
published
at the end of the summer. If his statements are credible, his
work
is more advanced than that of the Human Genome Project, but he
prefers
to delay its publication in order to present the data in a more
organized
manner than his rivals.
Progress
in Project
The
total cost to produce June's working draft of the Human Genome
Project
stands at $250 million. The final version will be ready by 2003,
according
to the project's sources. Just four months ago, the project
reached
the 1 billion base pair milestone. The long delay for the final
product
is caused by extensive testing for accuracy. The two billion
base
pairs now mapped by the project actually represent fifteen billion
base
pairs mapped out by various researchers. Each approved pair has
been
confirmed by at least four experiments. The final project will have
each
area confirmed at least eight times.
"It's
good news that we're moving so fast but it's even better news that
researchers
throughout the world are using this data now to investigate
the
genetic underpinnings of health and diseases ranging from
Alzheimer's
to diabetes," said Dr. Francis Collins, director of NIH's
National
Human Genome Research Institute, in a speech Friday at the BIO
2000
annual international biotechnology conference in Boston.
Freely
Available to All
Free
access to this information was recently reinforced in statements by
U.S.
President Bill Clinton, and British Prime Minister Tony Blair.
Clinton
told scientists on March 14, the United States pledges "to lead
a
global effort to make the raw data from DNA sequencing available to
scientists
everywhere, to benefit people everywhere. To this end, I am
pleased
to announce a ground-breaking agreement between the United
States
and the United Kingdom, one which I reconfirmed just a few hours
ago
in a conversation with Prime Minister Blair."
"This
agreement says in the strongest possible terms our genome, the
book
in which all human life is written, belongs to every member of the
human
race," asserted the U.S. President. "Already the Human
Genome
Project,
funded by the United States and the United Kingdom, requires
its
grant recipients to make the sequences they discover publicly
available
within 24 hours. I urge all other nations, scientists and
corporations
to adopt this policy and honor its spirit. We must ensure
that
the profits of human genome research are measured not in dollars,
but
in the betterment of human life."
To
their voices were added those of several of the highest scientific
academic
authorities. The statements caused a drop in the stock value of
bio-technological
firms.
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